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This book provides a thorough update on the management of infections in patients with hematologic malignancies, focusing particularly on prevention, diagnosis, and treatment. Detailed attention is devoted to the central roles that vaccination and anti-infective prophylaxis have gained in improving overall survival in this patient group, in accordance with the principle that prevention is better than cure. Careful consideration is also paid to risk stratification, which is crucial in ensuring that anti-infective prophylaxis is targeted to those at the highest risk. While preventive strategies reduce the prevalence of infections, optimized management strategies are vital to decrease infection-related morbidity and mortality in those who nevertheless develop infections. Here, readers will find in-depth, up-to-date knowledge on the diagnosis and treatment of bacterial, fungal, viral, and parasitic infections, according to the affected organ and the causative pathogen. Finally, treatment in intensive care units is reviewed. The book will be of high value for hematologists, oncologists, and infection specialists.

Hematology. --- Infectious diseases. --- Infectious Diseases. --- Haematology --- Internal medicine --- Blood --- Diseases --- Bloodborne infections. --- Blood-borne diseases --- Blood-borne infections --- Bloodborne diseases --- Bloodborne infection --- Communicable diseases --- Infection --- Transmission

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This book discusses specific immune cell regulatory pathway(s), immune cell types, or other mechanisms involved in host responses to tuberculosis that can be potentially targeted for host-directed therapy (HDT). The pathways/mechanisms investigated are either protective – thus calling for pathway/factor enhancing drugs – or maladaptive – thus calling for pathway/factor inhibitory drugs. Discovery and development (pre-clinical and clinical) of candidate HDT agents will also be elucidated, as well as approaches for HDT of other diseases. The benefit to the reader will derive from learning about the biology of multiple host pathways involved in health and disease, how these pathways are disrupted or dysregulated during tuberculosis, and which druggable targets exist in these pathways. This book provides the reader with a roadmap of current and future directions of HDT against tuberculosis. Since the host pathways/factors involved in protective or maladaptive responses to tuberculosis are not disease-specific, information learned from the context of tuberculosis likely will be relevant to other infectious and non-infectious diseases.

Immunology. --- Infectious diseases. --- Pharmacotherapy. --- Infectious Diseases. --- Drug therapy --- Pharmacotherapy --- Therapeutics --- Drugs --- Pharmacology --- Immunobiology --- Life sciences --- Serology --- Immunotherapy. --- Therapeutic immunology --- Clinical immunology

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Infection --- Mathematical models. --- Infectious diseases --- Diseases --- Medical microbiology --- Causes and theories of causation

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Nooit eerder heeft een pandemie een zo grote invloed gehad op de wereldbevolking als geheel als de covid-19-pandemie, ook wel bekend als de corona-pandemie. Sinds de uitbraak eind 2019 in China - vandaar het getal 19 - zijn reeds miljoenen mensen gestorven, maar het zijn vooral de maatregelen die de regeringen hebben genomen die ons dagelijks leven hebben beïnvloed: het verplicht dragen van mondkapjes, reis- en recreatieverboden en het nagenoeg onmogelijk maken van contact met andere mensen die niet bij ons thuis wonen. Nog altijd domineert de berichtgeving van deze ziekte het dagelijks nieuws. Toch is dit niet de eerste pandemie die de wereld getroffen heeft, verre van dat. Sinds de 'pest' van Athene, 2500 jaar geleden - de eerste epidemie die schriftelijk is vastgelegd - is de wereld regelmatig opgeschrikt door weer nieuwe ziekten en epidemieën, meestal afkomstig van elders, die soms hele continenten konden treffen. Vaak werd daarbij een nog groter deel van de bevolking getroffen dan in onze huidige pandemie. Desastreus was de 'Zwarte Dood', de beruchte pestepidemie die Europa rond het midden van de veertiende eeuw trof; soms stierf het grootste deel van de bevolking in een gebied uit. De indianen werden veel meer getroffen door mazelen dan Spaanse zwaarden; de Europeanen op hun beurt - zij het op kleinere schaal - door syfilis. Ruim honderd jaar geleden veroorzaakte de Spaanse griep (die overigens niet in Spanje is begonnen) meer slachtoffers dan de Eerste Wereldoorlog. In dit boek komen deze epidemieën aan bod. Vanuit verschillende gezichtspunten worden ze besproken: de symptomen, de aanvankelijke machteloosheid, de maatregelen van de regeringen, het uiteindelijke succes van de geneeskunde en de nasleep. We weten nu dat niet Apollo, Asklepios of God maar virussen verantwoordelijk zijn voor deze pandemie, maar het heet eeuwen geduurd voordat we dit inzicht hadden. Tegenwoordig lijkt de covid-19-pandemie op zijn retour: de cijfers dalen en maatregelen worden versoepeld, maar de belangrijkste reden is dat er steeds meer mensen gevaccineerd zijn. Vaccinatie is een uitvinding die dateert uit het eind van de achttiende eeuw en werd vanaf 1800 met succes toegepast. Ook nu.

History of human medicine --- Epidemiology --- pandemie --- epidemiologie --- covid-19 --- corona --- epidemieën --- pandemieën --- Infectious diseases. Communicable diseases --- coronacrisis

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"In this timely, wide-ranging and inspiring book, Jonathan Charteris-Black provides detailed and critical insights into the key roles played by metaphor and metonymy in framing the debate around the Covid-19 pandemic. He shows how, through their strong appeal to emotion, metaphors and metonyms form part of an 'overt moral coercion' which reduces the agency of those living through the pandemic. This book deepens our understanding of the ways in which the use of metaphor and metonymy can be used to shape behaviour, providing important insights into the collective experience of the pandemic. The chapter on metonymy is particularly illuminating as it highlights the different ways in which thought and behaviour during the Pandemic have been influenced by this highly subtle and nuanced form of communication which has been employed both in verbal format and through the use of images." -Jeannette Littlemore, Professor of English Language and Applied Linguistics, University of Birmingham, UK "This is a highly engaging, personal and lucid analysis of the figurative language used in the COVID-19 pandemic to 'make sense' of its threat to society and of the chances to counter it. Using both corpus-based and experimental survey methods, Charteris-Black expertly analyses key metaphors, metonymies and allegories about the virus, its worldwide spread and its medical management and relates them to fundamental parameters of moral judgement, leading to fascinating new insights." -Andreas Musolff, Professor of Intercultural Communication, University of East Anglia, UK This book explores the metaphors used in public and media communication to ask how language shapes our moral reasoning about the global coronavirus crisis. The author offers insights into the metaphors, metonyms, allegories and symbols of the global crisis and examines how they have contributed to policy formation and communication. Combining metaphor theory with moral foundations theory, he places metaphors in their historical contexts, and then critically questions why certain tropes might be used in particular situations to persuade and convince an audience. The book takes an integrated approach, involving ideas from cognitive linguistics, history, social psychology and literature to produce a multi-layered and thematically rich interpretation of the language of the pandemic and its social and political consequences. It will be relevant to readers with a background in these areas, as well as anyone with a general interest in the language used to make sense of this global event. Jonathan Charteris-Black is Professor of Linguistics at the University of the West of England, UK. His research interests include metaphor, rhetoric and political discourse. .

Infectious diseases. Communicable diseases --- Lexicology. Semantics --- psychologie --- wetenschap --- technologie --- linguïstiek --- psycholinguïstiek --- antropologie --- COVID-19 (Disease) --- Language and ethics.